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The sexual function effects of MT-2 are centrally mediated through hypothalamic melanocortin circuits, not through peripheral vascular mechanisms, which distinguishes MT-2 from PDE5 inhibitors and explains its effectiveness in patients where desire and arousal motivation, rather than vascular mechanics, is the limiting factor
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These supplements can also contain potentially dangerous levels of vitamins and minerals (48)
The potential for tachyphylaxis or tolerance development requires monitoring with chronic peptide therapy
